Hydrochloric Acid → HCID 67548065, compound

HRID 2356746Notes

Reaction equation

HRID 2356746 reaction equation
C(OC([NH:8][CH:9]([CH2:18][CH3:19])[C:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)=[O:11])=O)(C)(C)C.[ClH:20]>C(O)C>[ClH:20].[ClH:20].[NH2:8][CH:9]([CH2:18][CH3:19])[C:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67548190HCID 67548190, compound

Product 1

HCID 67548065HCID 67548065, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(t-butoxycarbonylamino)-1-(3-pyridyl)-1-butanone (20.50 g) and 6N hydrochloric acid (38.8 ml) in ethanol (100 ml) was refluxed for one hour. After cooling, the reaction mixture was concentrated under reduced pressure and the resulting residue was triturated with ethanol-ethylacetate (1:1) to obtain 2-amino-1-(3-pyridyl)-1-butanone dihydrochloride (13.40 g) as pale reddish purple crystalline powder.

Workup

  1. temperaturewas refluxed for one hour
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customthe resulting residue was triturated with ethanol-ethylacetate (1:1)

Sources & evidence

ORD record
ord-b92074297f3f4433a82ae6c12a4e7b5a
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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