Sodium Hydroxide → HCID 67547197, compound

HRID 2356761Notes

Reaction equation

HRID 2356761 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[CH:6][N:5]=1.[OH-].[Na+:15]>CO>[Na+:15].[CH3:1][O:2][CH2:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O-:10])=[O:9])=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54209632HCID 54209632, compound

Product 1

HCID 67547197HCID 67547197, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 6-methoxymethylnicotinate (737 mg) in a 2N aqueous sodium hydroxide solution (2 ml) and methanol (15 ml) was refluxed overnight. After cooling, the reaction mixture was concentrated under reduced pressure, and the resulting residue was triturated with diethyl ether to obtain 6-methoxymethylnicotinic acid sodium salt (754 mg) as colorless powder.

Workup

  1. temperaturewas refluxed overnight
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customthe resulting residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-074b9f14a08146e58fbddb9ed063fd1d
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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