Sulfuryl chloride → 2-Chloro-6-fluorobenzothiazole

HRID 2356795Notes

Reaction equation

HRID 2356795 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7](S)[S:8][C:4]=2[CH:3]=1.S(Cl)([Cl:15])(=O)=O>>[Cl:15][C:7]1[S:8][C:4]2[CH:3]=[C:2]([F:1])[CH:11]=[CH:10][C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 24648Sulfuryl chlorideHCID 178505461HCID 178505461, compound

Product 1

HCID 20498702-Chloro-6-fluorobenzothiazole

Procedure

6-Fluoro-benzothiazole-2-thiol was treated with sulfuryl chloride by the procedure described in PCT/US04/14036 to give the desired product, which was used in the next step without further purification. EI-MS m/z 187 (M+); 1H NMR (DMSO-d6) δ 8.00 (m, 2H), 7.40 (m, 1H).

Sources & evidence

ORD record
ord-ec38302bd07d493e98a1b083e63ff14c
Source dataset
uspto-grants-2010_07
Patent number
US07759376B2

Reaction notes

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