3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → HCID 59385245, compound

HRID 2356812Notes

Reaction equation

HRID 2356812 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][C:11]3[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:4]([F:19])[CH:3]=1.[F:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][C:26]=1[C:27]([O:29]C)=[O:28]>>[F:20][C:21]1[CH:22]=[C:23]([C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9]3[S:10][C:11]4[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=4[N:13]=3)=[C:4]([F:19])[CH:3]=2)[CH:24]=[CH:25][C:26]=1[C:27]([OH:29])=[O:28]

Participants

3

Reactant 2

HCID 27828183-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 7147089N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine

Product 1

HCID 59385245HCID 59385245, compound

Procedure

As shown in Reaction Scheme 8, Intermediate VI-8 (3,3′-difluoro-4′-[(6-fluoro-1,3-benzothiazol-2-yl)amino]biphenyl-4-carboxylic acid) was prepared using a method similar to that employed in the preparation of Intermediate VI-1 using N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine and commercially available [3-fluoro-4-(methoxycarbonyl)phenyl]boronic acid as starting materials.

Workup

  1. customAs shown in Reaction Scheme 8, Intermediate
  2. customthat employed in the preparation of Intermediate VI-1

Sources & evidence

ORD record
ord-ee5c10bd1c114e4b9840cac43cab4a0d
Source dataset
uspto-grants-2010_07
Patent number
US07759376B2

Reaction notes

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