HCID 68459821, compound → HCID 178472255, compound

HRID 2356853Notes

Reaction equation

HRID 2356853 reaction equation
C([N:5]1[C:9]([N:10]([NH:19][C:20](=[O:30])[CH2:21][C:22]2[CH:27]=[C:26]([F:28])[CH:25]=[C:24]([F:29])[CH:23]=2)[C:11](=[O:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:8][C:7]([C:31]([CH3:34])([CH3:33])[CH3:32])=[N:6]1)(C)(C)C>C(O)=O.O>[C:31]([C:7]1[CH:8]=[C:9]([N:10]([NH:19][C:20](=[O:30])[CH2:21][C:22]2[CH:23]=[C:24]([F:29])[CH:25]=[C:26]([F:28])[CH:27]=2)[C:11](=[O:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[NH:5][N:6]=1)([CH3:32])([CH3:33])[CH3:34]

Participants

4

Reactant 1

HCID 68459821HCID 68459821, compound

Product 1

HCID 178472255HCID 178472255, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

250 mg of compound 23 (Example 119) was refluxed in 3 mL of formic acid for 20 min. The mixture was cooled to 25° C. and diluted with 12 mL of distilled water. The resulting precipitate was collected by filtration and dried in a stream of air. It was suspended in 5 mL of chloroform and filtered. The solvent was evaporated from the filtrate at reduced pressure. The residue was stirred with 5 mL of tert-butyl methyl ether for one hour, and then recovered by filtration. The product was obtained as a white powder. Analysis gave 56.84% C, 5.87% H, 13.28% N.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customdried in a stream of air
  3. filtrationfiltered
  4. customThe solvent was evaporated from the filtrate at reduced pressure
  5. filtrationrecovered by filtration
  6. customThe product was obtained as a white powder
  7. customAnalysis gave 56.84% C, 5.87% H, 13.28% N

Sources & evidence

ORD record
ord-c68e0ae5d1cb4ef394aa05316b7086b7
Source dataset
uspto-grants-2010_07
Patent number
US07759382B2

Reaction notes

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