Hydrochloric Acid → HCID 23110295, compound

HRID 2356949Notes

Reaction equation

HRID 2356949 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[C:21]([N:23]3[C:27](=[O:28])[C:26]([CH3:30])([CH3:29])[N:25]([CH2:31][C:32]4[C:41]5[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=5)[N:35]=[CH:34][CH:33]=4)[C:24]3=[O:42])[CH:20]=[CH:19][C:18]=2[O:43][CH3:44])[CH2:9]1)=O)(C)(C)C.Cl>CO>[CH3:44][O:43][C:18]1[CH:19]=[CH:20][C:21]([N:23]2[C:27](=[O:28])[C:26]([CH3:30])([CH3:29])[N:25]([CH2:31][C:32]3[C:41]4[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=4)[N:35]=[CH:34][CH:33]=3)[C:24]2=[O:42])=[CH:22][C:17]=1[O:16][CH2:15][CH2:14][NH:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66915792HCID 66915792, compound

Product 1

HCID 23110295HCID 23110295, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 40 mg 3-{2-[5-(4,4-dimethyl-2,5-dioxo-3-quinolin-4-ylmethyl-imidazolidin-1-yl)-2-methoxy-phenoxy]-ethylamino}-pyrrolidine-1-carboxylic acid tert-butyl ester in 2 ml of a 8 N solution of hydrochloric acid in methanol was stirred for 1 hour at room temperature. After removal of the solvent under reduced pressure the residue was dissolved in a mixture of 2 ml water and 1 ml acetonitrile. Lyophilization of the resulting mixture yielded a white foam. The product was obtained as its hydrochloric salt.

Workup

  1. customAfter removal of the solvent under reduced pressure the residue
  2. dissolutionwas dissolved in a mixture of 2 ml water and 1 ml acetonitrile
  3. customLyophilization of the resulting mixture yielded a white foam
  4. customThe product was obtained as its hydrochloric salt

Sources & evidence

ORD record
ord-c2792586c33243a5969c5936e8adaf01
Source dataset
uspto-grants-2010_07
Patent number
US07759379B2

Reaction notes

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