HCID 21959486, compound → HCID 21959666, compound

HRID 2356967Notes

Reaction equation

HRID 2356967 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([N+:24]([O-])=O)[CH:22]=3)[C:17]([CH3:28])([CH3:27])[CH2:16]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([NH2:24])[CH:22]=3)[C:17]([CH3:28])([CH3:27])[CH2:16]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 21959486HCID 21959486, compound

Product 1

HCID 21959666HCID 21959666, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 240 mg 4-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester, 20 mg of 10% palladium on carbon and 5 ml ethanol was stirred for 3 hours under hydrogen atmosphere. The mixture was filtered through a chem elut cartridge and the compound was eluted with ethanol. After concentration under reduced pressure the residue was directly subjected to the subsequent reaction without further purification.

Workup

  1. filtrationThe mixture was filtered through a chem elut cartridge
  2. washthe compound was eluted with ethanol
  3. concentrationAfter concentration under reduced pressure the residue
  4. customwas directly subjected to the subsequent reaction without further purification

Sources & evidence

ORD record
ord-930f67b0adc14975a17517d4e51af4b9
Source dataset
uspto-grants-2010_07
Patent number
US07759379B2

Reaction notes

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