Sodium Hydroxide → HCID 58668693, compound

HRID 2356982Notes

Reaction equation

HRID 2356982 reaction equation
C([O:3][C:4](=[O:36])[C:5]([C:31]([O:33]CC)=[O:32])([CH:11]1[C:20]2[C:15](=[CH:16][C:17]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)(=[O:23])=[O:22])=[CH:18][CH:19]=2)[O:14][CH2:13][CH2:12]1)[C:6]([O:8]CC)=[O:7])C.[OH-].[Na+]>CO>[C:31]([C:5]([CH:11]1[C:20]2[C:15](=[CH:16][C:17]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)(=[O:23])=[O:22])=[CH:18][CH:19]=2)[O:14][CH2:13][CH2:12]1)([C:4]([OH:36])=[O:3])[C:6]([OH:8])=[O:7])([OH:33])=[O:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58668698HCID 58668698, compound

Product 1

HCID 58668693HCID 58668693, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of 2-Ethoxycarbonyl-2-[7-(3-fluoro-benzenesulfonyl)-chroman-4-yl]-malonicacid diethyl ester (5.0 g, 9.6 mmol) in MeOH (50 ml) was added NaOH (25 ml, 3N in H2O). The milky mixture was heated at 65° C. overnight. The solvent was evaporated to give crude 2-Carboxy-2-[7-(3-fluoro-benzenesulfonyl)-chroman-4-yl]-malonic acid as a solid.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-2c641e33b27a4eacb8ca13a2b5b15813
Source dataset
uspto-grants-2010_07
Patent number
US07759389B2

Reaction notes

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