Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 58668698 | HCID 58668698 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58668693 | HCID 58668693 | — |
Reaction Steps
To a solution of 2-Ethoxycarbonyl-2-[7-(3-fluoro-benzenesulfonyl)-chroman-4-yl]-malonicacid diethyl ester (5.0 g, 9.6 mmol) in MeOH (50 ml) was added NaOH (25 ml, 3N in H2O). The milky mixture was heated at 65° C. overnight. The solvent was evaporated to give crude 2-Carboxy-2-[7-(3-fluoro-benzenesulfonyl)-chroman-4-yl]-malonic acid as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07759389B2 |
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| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-2c641e33b27a4eacb8ca13a2b5b15813 |
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| Source note | uspto-grants-2010_07 |
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