HCID 58668693, compound → HCID 58668700, compound

HRID 2356983Notes

Reaction equation

HRID 2356983 reaction equation
[C:1]([C:4]([CH:11]1[C:20]2[C:15](=[CH:16][C:17]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)(=[O:23])=[O:22])=[CH:18][CH:19]=2)[O:14][CH2:13][CH2:12]1)(C(O)=O)C(O)=O)([OH:3])=[O:2]>CC(O)=O>[F:30][C:26]1[CH:25]=[C:24]([S:21]([C:17]2[CH:16]=[C:15]3[C:20]([CH:11]([CH2:4][C:1]([OH:3])=[O:2])[CH2:12][CH2:13][O:14]3)=[CH:19][CH:18]=2)(=[O:23])=[O:22])[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 1

HCID 58668693HCID 58668693, compound

Product 1

HCID 58668700HCID 58668700, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

The crude 2-Carboxy-2-[7-(3-fluoro-benzenesulfonyl)-chroman-4-yl]-malonic acid of step 3 was dissolved in HOAc (50 ml), and the mixture was heated to 100° C. overnight. HOAc was removed via vacuum, and he residue was dissolved in EtOAc, washed with H2O, brine, dried with MgSO4, filtered and concentrated to give [7-(3-Fluoro-benzenesulfonyl)-chroman-4-yl]-acetic acid as a colorless oil which turned to a white solid upon standing: 2.55 g; MS 373(M+Na)+, 723.3 (2M+Na)+.

Workup

  1. customHOAc was removed via vacuum, and he residue
  2. dissolutionwas dissolved in EtOAc
  3. washwashed with H2O, brine
  4. dry with materialdried with MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-5d0dd0de5e4541d182415244c596e3be
Source dataset
uspto-grants-2010_07
Patent number
US07759389B2

Reaction notes

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