Acetonitrile--water (1/1) → 4-(4-Phenylbutoxy)-3-(trifluoromethyl)benzoic acid

HRID 2357062Notes

Reaction equation

HRID 2357062 reaction equation
[CH2:1]([O:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=1[C:19]([F:22])([F:21])[F:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:23](#N)[CH3:24].O>>[C:5]1([CH2:4][CH2:3][CH2:2][CH2:1][O:9][C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=2[C:19]([F:20])([F:21])[F:22])[CH:24]=[CH:23][CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 18373917Acetonitrile--water (1/1)HCID 533492554-Octyloxy-3-trifluoromethylbenzoic acid

Product 1

HCID 593843554-(4-Phenylbutoxy)-3-(trifluoromethyl)benzoic acidYield 95%

Procedure

The title compound was prepared analogously to 4-(octyloxy)-3-(trifluoromethyl)benzoic acid (11a) in >95% yield. HPLC retention time on a C8(2) column (30×3.00 mm, 3μ) is 3.14 min with gradient 20-98% acetonitrile-H2O (0.1% TFA) in 3.5 min as mobile phase.

Sources & evidence

ORD record
ord-be20d7cdcece49d2856dd02bae977cfe
Source dataset
uspto-grants-2010_07
Patent number
US07759370B2

Reaction notes

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