HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile--water (1/1) → 4-(4-Phenylbutoxy)-3-(trifluoromethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Reactant | 4-Octyloxy-3-trifluoromethylbenzoic acid | HCID 53349255 | — |
| Product | 4-(4-Phenylbutoxy)-3-(trifluoromethyl)benzoic acid | HCID 59384355 | 95% |
Reaction Steps
The title compound was prepared analogously to 4-(octyloxy)-3-(trifluoromethyl)benzoic acid (11a) in >95% yield. HPLC retention time on a C8(2) column (30×3.00 mm, 3μ) is 3.14 min with gradient 20-98% acetonitrile-H2O (0.1% TFA) in 3.5 min as mobile phase.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759370B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-be20d7cdcece49d2856dd02bae977cfe |
| Source note | uspto-grants-2010_07 |