Acetonitrile--water (1/1) → HCID 59384403, compound

HRID 2357064Notes

Reaction equation

HRID 2357064 reaction equation
[CH2:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([NH:16][NH2:17])=[O:15])=[CH:12][C:11]=1[C:20]([F:23])([F:22])[F:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:24](#N)[CH3:25].O>>[C:5]1([CH2:4][CH2:3][CH2:2][CH2:1][O:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([NH:16][NH2:17])=[O:15])=[CH:12][C:11]=2[C:20]([F:21])([F:22])[F:23])[CH:25]=[CH:24][CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 18373917Acetonitrile--water (1/1)HCID 533493604-(Octyloxy)-3-(trifluoromethyl)benzohydrazide

Product 1

HCID 59384403HCID 59384403, compoundYield 95%

Procedure

The title compound was prepared analogously to 4-(octyloxy)-3-(trifluoromethyl)-benzo-hydrazide (12a) in >95% yield. MS (ESI): 353.11 (MH+); HPLC retention time on a C8(2) column (30×3.00 mm, 3μ) is 2.30 min with gradient 20-98% acetonitrile-H2O (0.1% TFA) in 3.5 min as mobile phase.

Sources & evidence

ORD record
ord-c78079a61b1e46329384c74ce90433b4
Source dataset
uspto-grants-2010_07
Patent number
US07759370B2

Reaction notes

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