HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Coumarin 343 aminopropionic Acid-tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Coumarin 343 | HCID 108770 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | Tert-butyl 2-aminopropanoate | HCID 4351123 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Coumarin 343 aminopropionic Acid-tert-butyl Ester | HCID 131728253 | — |
Reaction Steps
285 mg Coumarin 343 (1 mmol), 262 mg aminopropionic acid tert. butyl ester (1.2 mmol) and 343 mg HBTU (1.2 mmol) were dissolved in 5 ml of dry DMF. 280 μl triethylamine were added and the solution was stirred for 2 hours at room temperature. The solvent was evaporated in a vacuum on a rotary evaporator and the product was purified by column chromatography (silica gel 60, Merck, mobile phase: ethyl acetate/methanol 2:1 (v/v)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759470B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-ca2a4478b5ce461999417b4c3f8ac248 |
| Source note | uspto-grants-2010_07 |