反应详情

285 mg Coumarin 343 (1 mmol), 262 mg aminopropionic acid tert. butyl ester (1.2 mmol) and 343 mg HBTU (1.2 mmol) were dissolved in 5 ml of dry DMF. 280 μl triethylamine were added and the solution was stirred for 2 hours at room temperature. The solvent was evaporated in a vacuum on a rotary evaporator and the product was purified by column chromatography (silica gel 60, Merck, mobile phase: ethyl acetate/methanol 2:1 (v/v)).

1. customThe solvent was evaporated in a vacuum on a rotary evaporator
2. customthe product was purified by column chromatography (silica gel 60, Merck, mobile phase: ethyl acetate/methanol 2:1 (v/v))