HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(Dimethylamino)-1-(2-thienyl)-1-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2-Acetylthiophene | HCID 6920 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-(Dimethylamino)-1-(2-thienyl)-1-propanone | HCID 408257 | — |
Reaction Steps
An example of a method known for producing N,N-dimethyl-3-hydroxy-3-(2-thienyl)propanamine is reacting 2-acetylthiophene with a dimethylamine hydrochloride in isopropanol in the presence of paraformaldehyde and hydrochloric acid to give 2-thienyl 2-dimethylaminoethyl ketone, and reducing this ketone with sodium borohydride in ethanol (Japanese Unexamined Patent Publication No. 1995-188065).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759501B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-289aa45e931d413c964c41321dc4ff5e |
| Source note | uspto-grants-2010_07 |