Hydrochloric Acid → 3-(Dimethylamino)-1-(2-thienyl)-1-propanone

HRID 2357119Notes

Reaction equation

HRID 2357119 reaction equation
[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].Cl.[CH3:10][NH:11][CH3:12].[CH2:13]=O.Cl>C(O)(C)C>[CH3:10][N:11]([CH3:13])[CH2:12][CH2:2][C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 69202-AcetylthiopheneHCID 10473Dimethylamine, hydrochloride

Product 1

HCID 4082573-(Dimethylamino)-1-(2-thienyl)-1-propanone

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

An example of a method known for producing N,N-dimethyl-3-hydroxy-3-(2-thienyl)propanamine is reacting 2-acetylthiophene with a dimethylamine hydrochloride in isopropanol in the presence of paraformaldehyde and hydrochloric acid to give 2-thienyl 2-dimethylaminoethyl ketone, and reducing this ketone with sodium borohydride in ethanol (Japanese Unexamined Patent Publication No. 1995-188065).

Sources & evidence

ORD record
ord-289aa45e931d413c964c41321dc4ff5e
Source dataset
uspto-grants-2010_07
Patent number
US07759501B2

Reaction notes

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