反应详情

To a solution of about 13.78 g of 1-(4-tetradecyl phenoxy)-3-(triphenylmethoxy)-2-propanol in about 45 ml of dimethylformamide was added a suspension of about 1.426 g of ether pre-washed sodium hydride in about 10 ml of dimethylformamide, followed by a solution of about 4.06 g of benzylbromide in about 5 ml of dimethylformamide. The mixture was stirred under argon for about 3 hours, quenched very slowly with water and extracted twice with about 50% ether in hexane. The organic layer was dried, filtered and the solvents removed, giving about 15.7 g of the desired title compound.

1. washpre-washed sodium hydride in about 10 ml of dimethylformamide
2. customquenched very slowly with water
3. extractionextracted twice with about 50% ether in hexane
4. customThe organic layer was dried
5. filtrationfiltered
6. customthe solvents removed