Methyl iodide → 1-[2-Methoxy-3-(triphenylmethoxy)propoxy]-4-tetradecylbenzene

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Reaction Steps

To a solution of about 558 mg of 1-(4-tetradecylphenoxy)-3-(triphenylmethoxy)-2-propanol in about 5 ml of dry dimethylformamide was added a prewashed suspension of about 66 mg of sodium hydride in about 2 ml of dimethylformamide followed by about 157 mg of iodomethane. The mixture was stirred under argon for about 2 hours, quenched slowly with water and extracted twice with ether:hexane (about 1:1). The extracts were combined, dried, and the solvents evaporated, giving about 560 mg of the desired title compound.

Provenance & Evidence