Hydrochloric Acid → HCID 10096611, compound

Participants

Reaction Steps

5.5M isopropanolic hydrochloric acid (0.44 ml, 2.43 mmole) was added to a solution of the polar diastereoisomer of {1-(4-fluorophenyl)-4-[3-(1H-indol-3-yl)pyrrolidine-1-yl]cyclohexyl}-dimethylamine (330 mg, 0.81 mmole) in ethyl methyl ketone (25 ml) and methanol (5 ml). After a reaction time of 2 hours the polar dihydrochloride (Example 12) with an m.p. of 223°-230° C. was filtered off in a yield of 92% (358 mg).

Provenance & Evidence