Hydrochloric Acid → HCID 10096611, compound

HRID 2357445Notes

Reaction equation

HRID 2357445 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([N:29]([CH3:31])[CH3:30])[CH2:14][CH2:13][CH:12]([N:15]3[CH2:19][CH2:18][CH:17]([C:20]4[C:28]5[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=5)[NH:22][CH:21]=4)[CH2:16]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>CC(CC)=O.CO>[ClH:1].[ClH:1].[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2([N:29]([CH3:31])[CH3:30])[CH2:14][CH2:13][CH:12]([N:15]3[CH2:19][CH2:18][CH:17]([C:20]4[C:28]5[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=5)[NH:22][CH:21]=4)[CH2:16]3)[CH2:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10096612HCID 10096612, compound

Product 1

HCID 10096611HCID 10096611, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6569Methyl Ethyl KetoneSolvent

Procedure

5.5M isopropanolic hydrochloric acid (0.44 ml, 2.43 mmole) was added to a solution of the polar diastereoisomer of {1-(4-fluorophenyl)-4-[3-(1H-indol-3-yl)pyrrolidine-1-yl]cyclohexyl}-dimethylamine (330 mg, 0.81 mmole) in ethyl methyl ketone (25 ml) and methanol (5 ml). After a reaction time of 2 hours the polar dihydrochloride (Example 12) with an m.p. of 223°-230° C. was filtered off in a yield of 92% (358 mg).

Workup

  1. filtrationAfter a reaction time of 2 hours the polar dihydrochloride (Example 12) with an m.p. of 223°-230° C. was filtered off in a yield of 92% (358 mg)

Sources & evidence

ORD record
ord-a63a3a5266564016bb7fca2f3081d73e
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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