Chlorotrimethylsilane → HCID 10050641, compound

HRID 2357455Notes

Reaction equation

HRID 2357455 reaction equation
[CH3:1][N:2]([CH3:33])[C:3]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][CH:19]=3)[CH2:14][CH2:13]2)=[O:11])[CH2:5][CH2:4]1.[Cl:34][Si](C)(C)C>CC(CC)=O>[ClH:34].[CH3:33][N:2]([CH3:1])[C:3]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([N:12]2[CH2:13][CH:14]=[C:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][CH:19]=3)[CH2:16][CH2:17]2)=[O:11])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 10050642HCID 10050642, compound

Product 1

HCID 10050641HCID 10050641, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-(4-dimethylamino-4-phenylcyclohexylidene)-1-[4-(1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]ethanone (150 mg, 0.34 mmole) was dissolved in ethyl methyl ketone (3 ml) and chlorotrimethylsilane (0.063 ml, 0.5 mmole) was added. After 1 hour the hydrochloride was isolated as a reddish-brown solid with an m.p. of 177°-182° C. in a yield of 69% (112 mg) (Example 25).

Sources & evidence

ORD record
ord-5450bfa063414cf3b7cfd87725ea5888
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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