Chlorotrimethylsilane → HCID 10050641, compound

Participants

Reaction Steps

2-(4-dimethylamino-4-phenylcyclohexylidene)-1-[4-(1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]ethanone (150 mg, 0.34 mmole) was dissolved in ethyl methyl ketone (3 ml) and chlorotrimethylsilane (0.063 ml, 0.5 mmole) was added. After 1 hour the hydrochloride was isolated as a reddish-brown solid with an m.p. of 177°-182° C. in a yield of 69% (112 mg) (Example 25).

Provenance & Evidence