Chlorotrimethylsilane → HCID 9983900, compound

HRID 2357459Notes

Reaction equation

HRID 2357459 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:34])[CH:18]=[C:19]2[CH2:24][CH2:23][C:22]([N:31]([CH3:33])[CH3:32])([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:21][CH2:20]2)[CH2:13][CH2:12]1.Cl[Si](C)(C)C>CC(CC)=O>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:34])[CH:18]=[C:19]2[CH2:20][CH2:21][C:22]([N:31]([CH3:33])[CH3:32])([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:23][CH2:24]2)[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 9983901HCID 9983901, compound

Product 1

HCID 9983900HCID 9983900, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

1-[4-(5-chloro-1H-indol-3-yl)piperidine-1-yl]-2-(4-dimethylamino-4-phenylcyclohexylidene)-ethanone (167 mg, 0.35 mmole) was dissolved was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (0.067 ml, 0.53 mmole) was added. After 50 minutes the hydrochloride was isolated as a beige-coloured compound with an m.p. of 188°-190° C. in a yield of 73% (131 mg) (Example 27).

Sources & evidence

ORD record
ord-1949eb0e650d47e6a0e638f942549f1c
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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