反应详情

To prepare the hydrochloride the polar diastereoisomer of 3-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylic acid-(4-dimethylamino-4-phenylcyclohexyl)-amide (86 mg, 0.18 mmole) was dissolved in ethyl methyl ketone (3 ml) and chlorotrimethylsilane (34 μl, 0.27 mmole) was added. The solid thereby formed was filtered off and dried. The hydrochloride of the polar diastereoisomer of 3-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylic acid-(4-dimethylamino-4-phenylcyclohexyl)-amide was thereby obtained in a yield of 92 mg (100%) as a colourless solid (Example 36) with an m.p. of 158°-160° C.

1. customThe solid thereby formed
2. filtrationwas filtered off
3. customdried