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HRID2357473

反应详情

EQUATION

反应方程式

HRID 2357473 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)Cl
HCID6397

Chlorotrimethylsilane

C3H9ClSi

结构：CN(C)C1(c2ccccc2)CCC(CC(=O)N2CCC(c3c[nH]c4ccccc34)C2)CC1
HCID10004711

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C1(c2ccccc2)CCC(CC(=O)N2CCC(c3c[nH]c4ccccc34)C2)CC1.Cl
HCID10004710

未命名化合物

收率 94%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCC(C)=O
溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone (510 mg, 1.19 mmole) was dissolved in ethyl methyl ketone (15 ml) and chlorotrimethylsilane (0.226 ml, 1.8 mmole) was added. After 1 hour the hydrochloride was isolated as a colourless compound with an m.p. of 180°-191° C. in a yield of 94% (523 mg) (Example 39).