HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone | HCID 10004711 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone hydrochloride | HCID 10004710 | 94% |
Reaction Steps
2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone (510 mg, 1.19 mmole) was dissolved in ethyl methyl ketone (15 ml) and chlorotrimethylsilane (0.226 ml, 1.8 mmole) was added. After 1 hour the hydrochloride was isolated as a colourless compound with an m.p. of 180°-191° C. in a yield of 94% (523 mg) (Example 39).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759385B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-d57940d5f47b4b48a1d3230b2baf2824 |
| Source note | uspto-grants-2010_07 |