反应详情

The non-polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone (190 mg, 0.43 mmole) was dissolved in ethyl methyl ketone (10 ml) and chlorotrimethylsilane (0.08 ml, 0.63 mmole) was added. After a reaction time of 1.5 hours the hydrochloride was obtained in a yield of 100% (208 mg) as a colourless solid with an m.p. of 168°-173° C. (Example 40).