HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → HCID 10345215, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone | HCID 10345216 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 10345215 | HCID 10345215 | 100% |
Reaction Steps
The non-polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone (190 mg, 0.43 mmole) was dissolved in ethyl methyl ketone (10 ml) and chlorotrimethylsilane (0.08 ml, 0.63 mmole) was added. After a reaction time of 1.5 hours the hydrochloride was obtained in a yield of 100% (208 mg) as a colourless solid with an m.p. of 168°-173° C. (Example 40).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759385B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-0daf7897d022486db0df50384231d20d |
| Source note | uspto-grants-2010_07 |