Hydrochloric Acid → HCID 67532167, compound

HRID 2357495Notes

Reaction equation

HRID 2357495 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[C:12]1[CH2:13][CH2:14][N:15]([CH:18]2[CH2:23][CH2:22][C:21]([N:30]([CH3:32])[CH3:31])([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19]2)[CH2:16][CH:17]=1.[Cl:33][Si](C)(C)C>CC(CC)=O>[ClH:2].[ClH:33].[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[C:12]1[CH2:13][CH2:14][N:15]([CH:18]2[CH2:23][CH2:22][C:21]([N:30]([CH3:32])[CH3:31])([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19]2)[CH2:16][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 57438247HCID 57438247, compound

Product 1

HCID 67532167HCID 67532167, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To prepare the hydrochloride the diastereoisomer mixture of 4-[4-(5-chloro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]-1-phenylcyclohexyldimethylamine (340 mg, 0.79 mmole) was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (255 μL, 2.0 mmole) was added. The solid thereby formed was filtered off and dried. The hydrochloride was thereby obtained in a yield of 170 mg (46%) as a colourless solid (Example 55) with an m.p. of 210°-212° C.

Workup

  1. customThe solid thereby formed
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-b24861decf2f47e99c345d9f2cd24832
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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