Hydrochloric Acid → HCID 10027772, compound

Participants

Reaction Steps

To prepare the hydrochloride the diastereoisomer mixture of {4-[4-(1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]-1-phenylcyclohexyl}-dimethylamine (320 mg, 0.8 mmole) was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (255 μl, 2.0 mmole) was added. The solid thereby formed was filtered off and dried. The hydrochloride was thereby obtained in a yield of 378 mg (100%) as a colourless solid (Example 56) with an m.p. of 188°-191° C.

Provenance & Evidence