Hydrochloric Acid → HCID 10027772, compound

HRID 2357498Notes

Reaction equation

HRID 2357498 reaction equation
[ClH:1].[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[CH2:12][CH2:13][N:14]([CH:17]3[CH2:22][CH2:21][C:20]([N:29]([CH3:31])[CH3:30])([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:19][CH2:18]3)[CH2:15][CH:16]=2)=[CH:3]1.[Cl:32][Si](C)(C)C>CC(CC)=O>[ClH:32].[ClH:1].[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[CH2:12][CH2:13][N:14]([CH:17]3[CH2:18][CH2:19][C:20]([N:29]([CH3:31])[CH3:30])([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:21][CH2:22]3)[CH2:15][CH:16]=2)=[CH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 10027773HCID 10027773, compound

Product 1

HCID 10027772HCID 10027772, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To prepare the hydrochloride the diastereoisomer mixture of {4-[4-(1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]-1-phenylcyclohexyl}-dimethylamine (320 mg, 0.8 mmole) was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (255 μl, 2.0 mmole) was added. The solid thereby formed was filtered off and dried. The hydrochloride was thereby obtained in a yield of 378 mg (100%) as a colourless solid (Example 56) with an m.p. of 188°-191° C.

Workup

  1. customThe solid thereby formed
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-d9338f3e48e847c8a11464ad29df5cee
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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