Hydrochloric Acid → HCID 67531703, compound

HRID 2357501Notes

Reaction equation

HRID 2357501 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[C:13]1[CH2:14][CH2:15][N:16]([CH:19]2[CH2:24][CH2:23][C:22]([N:31]([CH3:33])[CH3:32])([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:21][CH2:20]2)[CH2:17][CH:18]=1.[Cl:34][Si](C)(C)C>CC(CC)=O>[ClH:34].[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[C:13]1[CH2:14][CH2:15][N:16]([CH:19]2[CH2:24][CH2:23][C:22]([N:31]([CH3:32])[CH3:33])([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:21][CH2:20]2)[CH2:17][CH:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 57438248HCID 57438248, compound

Product 1

HCID 67531703HCID 67531703, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To prepare the hydrochloride the diastereoisomer mixture of {4-[4-(5-methoxy-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]-1-phenylcyclohexyl}-dimethylamine (343 mg, 0.8 mmole) was dissolved in ethyl methyl ketone (5 ml) and chlorotrimethylsilane (255 μl, 2.0 mmole) was added. The solid thereby formed was filtered off and dried. The hydrochloride was thereby obtained in a yield of 400 mg (100%) as a colourless solid (Example 57) with an 15 m.p. of 201°-203° C.

Workup

  1. customThe solid thereby formed
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-53d097a460464eefbe976dfa9b7e03a1
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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