Hydrochloric Acid → HCID 10338495, compound

Participants

Reaction Steps

To prepare the hydrochloride the polar diastereoisomer of dimethyl(1-phenyl-4-piperidine-1-ylcyclohexyl)amine (92 mg, 0.32 mmole) was dissolved in ethyl methyl ketone (4 ml) and trimethylchlorosilane (102 μl, 0.8 mmole) was added. The solid thereby obtained was filtered off and dried. The hydrochloride of dimethyl(1-phenyl-4-piperidine-1-ylcyclohexyl)amine was thereby obtained as a colourless solid (Example 61) with an m.p. of 260°-261° C. in a yield of 103 mg (100%).

Provenance & Evidence