Hydrochloric Acid → HCID 10338495, compound

HRID 2357508Notes

Reaction equation

HRID 2357508 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:22])[C:4]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:9][CH2:8][CH:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:6][CH2:5]1.C[Si](C)(C)[Cl:25]>CC(CC)=O>[ClH:25].[ClH:1].[CH3:2][N:3]([CH3:22])[C:4]1([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:5][CH2:6][CH:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:8][CH2:9]1.[CH3:2][N:3]([CH3:22])[C:4]1([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:5][CH2:6][CH:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:8][CH2:9]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 10338496HCID 10338496, compound

Product 2

HCID 10338495HCID 10338495, compoundHCID 10338496HCID 10338496, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To prepare the hydrochloride the polar diastereoisomer of dimethyl(1-phenyl-4-piperidine-1-ylcyclohexyl)amine (92 mg, 0.32 mmole) was dissolved in ethyl methyl ketone (4 ml) and trimethylchlorosilane (102 μl, 0.8 mmole) was added. The solid thereby obtained was filtered off and dried. The hydrochloride of dimethyl(1-phenyl-4-piperidine-1-ylcyclohexyl)amine was thereby obtained as a colourless solid (Example 61) with an m.p. of 260°-261° C. in a yield of 103 mg (100%).

Workup

  1. customThe solid thereby obtained
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-f0eece9bfe05491ba6151912a1ef81e4
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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