反应详情

温度

150 °C

1,8-Diazabicyclo(5.4.0)-7-undecene (0.25 mL, 1.65 mmol) was added to N-cyclopropyl-2-fluoro-N′-hydroxy-3-iodo-4-methylbenzamidine (500 mg, 1.5 mmol) in anhydrous THF (2.0 mL) then heated in a microwave at 150° C. for 70 min. The solvents were evaporated and the residue was loaded on an ISCO column (40 g, eluted with 25-75% ethyl acetate in Hexanes) to provide the title compound as an off-white crystalline solid. MS (ESI, pos. ion) m/z: 315.0 (M+1).

1. customThe solvents were evaporated
2. washthe residue was loaded on an ISCO column (40 g, eluted with 25-75% ethyl acetate in Hexanes)