反应详情

To a solution of 6-bromo-1-chlorophthalazine (0.22 g, 0.9 mmol) in acetonitile (5 mL) stirred at ambient was added sodium ethanethiolate (0.2 g, 2 mmol), and the mixture was stirred for 1 h. The mixture was diluted with ethyl acetate (100 mL), washed with sat. NH4Cl, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by chromatography eluting with 1-5% 2 M ammonia methanol/dichloromethane to give the 6-bromo-1-(ethylthio)phthalazine as pale yellow solid.

1. washwashed with sat. NH4Cl
2. dry with materialdried over anhydrous Na2SO4
3. concentrationconcentrated under reduced pressure
4. customThe crude product was purified by chromatography
5. washeluting with 1-5% 2 M ammonia methanol/dichloromethane