HCID 68454064, compound → HCID 68454726, compound

HRID 2357621Notes

Reaction equation

HRID 2357621 reaction equation
[CH:1]1([NH:4][C:5](=[O:29])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)=[N:18][N:17]=[CH:16]4)[CH:7]=2)[CH2:3][CH2:2]1.C1(N[C:34](=[O:58])[C:35]2C=CC(C)=C(C3C=C4C(=CC=3)C(C3CCNCC3)=NN=C4)C=2)CC1>C(O)C>[C:34]([N:26]1[CH2:27][CH2:28][CH:23]([C:19]2[C:20]3[C:15](=[CH:14][C:13]([C:8]4[CH:7]=[C:6]([CH:11]=[CH:10][C:9]=4[CH3:12])[C:5]([NH:4][CH:1]4[CH2:2][CH2:3]4)=[O:29])=[CH:22][CH:21]=3)[CH:16]=[N:17][N:18]=2)[CH2:24][CH2:25]1)(=[O:58])[CH3:35]

Participants

3

Reactant 1

HCID 68454064HCID 68454064, compound

Product 1

HCID 68454726HCID 68454726, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-cyclopropyl-4-methyl-3-(1-(piperidin-4-yl)phthalazin-6-yl)benzamide N-cyclopropyl-4-methyl-3-(1-(piperidin-4-yl)phthalazin-6-yl)benzamide (29 μmol) in 2 mL ethanol was stirred at RT and treated with 2-trifluoromethylamine diacetate (142 μmol). The mixture was stirred at RT for 4 h, then purified directly by silica gel chromatography, eluting with 5% 2 M ammonia methanol/dichloromethane to give the title compound.

Workup

  1. stirringThe mixture was stirred at RT for 4 h
  2. custompurified directly by silica gel chromatography
  3. washeluting with 5% 2 M ammonia methanol/dichloromethane

Sources & evidence

ORD record
ord-02b3bf0faa714a6b99d51f19b9ea628e
Source dataset
uspto-grants-2010_07
Patent number
US07759337B2

Reaction notes

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