1-(Methylsulfonyl)piperazine → HCID 68452804, compound

HRID 2357633Notes

Reaction equation

HRID 2357633 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](Cl)=[N:7][N:6]=[CH:5]2.[CH3:13][S:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])=[O:15]>ClCCl.CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:20]1[CH2:21][CH2:22][N:17]([S:14]([CH3:13])(=[O:16])=[O:15])[CH2:18][CH2:19]1)=[N:7][N:6]=[CH:5]2

Participants

4

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 220304246-Bromo-1-chlorophthalazine

Product 1

HCID 68452804HCID 68452804, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Conditions

Temperature
120 °C

Procedure

6-Bromo-1-chlorophthalazine (18 mg, 74 umol) and 1-(methylsulfonyl)piperazine (91 mg, 554 μmol) were dissolved in dichloromethane/methanol when the reaction mixture was concentrated by evaporation under a nitrogen line. The concentrate was heated to 120° C. for 6 h to give the title compound. MS (ES+): 373 (M+H)+.

Workup

  1. concentrationwas concentrated by evaporation under a nitrogen line

Sources & evidence

ORD record
ord-59f013caca3947f5974040eff5713283
Source dataset
uspto-grants-2010_07
Patent number
US07759337B2

Reaction notes

Loading…