Methanol → HCID 178497700, compound

HRID 2357646Notes

Reaction equation

HRID 2357646 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=3[CH3:21])[C:15]([OH:17])=[O:16])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1.S(Cl)(Cl)=O.[CH3:26]O>>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=3[CH3:21])[C:15]([O:17][CH3:26])=[O:16])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178425877HCID 178425877, compound

Product 1

HCID 178497700HCID 178497700, compound

Conditions

Temperature
50 °C

Procedure

3-(1-Hydroxyphthalazin-6-yl)-4-methylbenzoic acid (2.71 g, 9.67 mmol) was suspended in methanol (96.7 mL), thionyl chloride (2.12 mL, 29.0 mmol) was added and the mixture was stirred at 50° C. for 1.5 h and at RT overnight. The mixture was concentrated to give the title compound. MS (ES+): 295(M+H)+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-026ba7a5091345a19e969aeee4fc0e49
Source dataset
uspto-grants-2010_07
Patent number
US07759337B2

Reaction notes

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