反应详情

温度

190 °C

In three separate sealed tubes were placed a mixture of 6-bromo-1-chlorophthalazine (0.250 g, 1.03 mmol), 3-methylpiperazin-2-one (0.239 g, 2.09 mmol), K2CO3 (0.155 g, 1.12 mmol) and 5 mL of CH3CN. The three reactions were heated at 190° C. for 15 min in a microwave oven. The reaction mixtures were combined, concentrated onto silica gel and purified using flash chromatography eluting with 2M NH3 in MeOH/CH2Cl2 (0:1→1:19) to give 200 mg (60%) of an orange oil.

1. customIn three separate
2. customsealed tubes
3. customThe reaction mixtures
4. concentrationconcentrated onto silica gel
5. custompurified
6. washeluting with 2M NH3 in MeOH/CH2Cl2 (0:1→1:19)