Hydrogen Peroxide → 3-((1S,2S)-1-Methyl-1-oxido-2-pyrrolidinyl)pyridine

HRID 235780Notes

Reaction equation

[OH:1]O.[N:3]1[CH:8]=[C:7]([CH:9]2[CH2:14][CH2:13][CH2:12][N:10]2[CH3:11])[CH:6]=[CH:5][CH:4]=1>>[CH3:11][N@@+:10]1([O-:1])[C@H:9]([C:7]2[CH:6]=[CH:5][CH:4]=[N:3][CH:8]=2)[CH2:14][CH2:13][CH2:12]1

Participants

Reactant 2

HCID 784Hydrogen Peroxide

HCID 9423-(1-Methylpyrrolidin-2-yl)pyridine

Product 1

HCID 123138593-((1S,2S)-1-Methyl-1-oxido-2-pyrrolidinyl)pyridine

Procedure

After a total reaction period of 5 hours, a nicotine conversion of 98% is obtained; the residual hydrogen peroxide content is 1.5%. The resulting oily solution of the oxidation products has a yellowish color and exhibits no odor of nicotine.

Sources & evidence

ORD record: ord-fde39bcb62594b60bf5c1a7a0090642e
Source dataset: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04641667

Reaction notes

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