Water → HCID 59304580, compound

HRID 2357877Notes

Reaction equation

HRID 2357877 reaction equation
[CH2:1]([C:3]1[C:12]2[C:11](=[O:13])[NH:10][C:9](=[S:14])[NH:8][C:7]=2[O:6][C:5](=[O:15])[CH:4]=1)[CH3:2].O.[CH3:17]N(C=O)C>>[CH2:1]([C:3]1[C:12]2[C:11](=[O:13])[NH:10][C:9]([S:14][CH3:17])=[N:8][C:7]=2[O:6][C:5](=[O:15])[CH:4]=1)[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 6228DimethylformamideHCID 533226895-ethyl-2-mercapto-3H-pyrano[2,3-d]pyrimidine-4,7-dione

Product 1

HCID 59304580HCID 59304580, compoundYield 96%

Procedure

Mel (2.23 mL, 35.72 mmol) was added to a suspension of 5-ethyl-2-thioxo-2,3-dihydro-1h-pyrano[2,3-d]pyrimidine-4,7-dione (4.0 g, 17.86 mmol) in DMF (40 mL) at room temperature. The reaction mixture was stirred at room temperature overnight. The reaction mixture was then poured into water (250 mL) and filtered through a sintered funnel. The solid residue was washed with water (2×50 mL) and dried under vacuum to give 5-ethyl-2-methylsulfanyl-3H-pyrano[2,3-d]pyrimidine-4,7-dione (4.1 g, 96%).

Workup

  1. filtrationfiltered through a sintered funnel
  2. washThe solid residue was washed with water (2×50 mL)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-97fd655668d64ad5ae02c0b86fa9b5ab
Source dataset
uspto-grants-2010_07
Patent number
US07763623B2

Reaction notes

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