Triethylamine → HCID 59389328, compound

HRID 2357924Notes

Reaction equation

HRID 2357924 reaction equation
C(N(CC)CC)C.[OH:8][CH:9]([C:11]1[CH:29]=[C:14]2[C:15]([C:21]3[CH:22]([CH3:28])[CH2:23][C:24](=[O:27])[NH:25][N:26]=3)=[CH:16][CH:17]=[C:18]([O:19][CH3:20])[N:13]2[N:12]=1)[CH3:10]>CS(C)=O>[C:9]([C:11]1[CH:29]=[C:14]2[C:15]([C:21]3[CH:22]([CH3:28])[CH2:23][C:24](=[O:27])[NH:25][N:26]=3)=[CH:16][CH:17]=[C:18]([O:19][CH3:20])[N:13]2[N:12]=1)(=[O:8])[CH3:10]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 59389404HCID 59389404, compound

Product 1

HCID 59389328HCID 59389328, compoundYield 59.8%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Triethylamine (1.46 mL) was added to a solution of the compound of Example 238 (315 mg) in DMSO (10 mL). While the mixture was stirred at room temperature, sulfur trioxide-pyridine complex (829 mg) was added at once and the mixture was further stirred at room temperature for 1 hour. Subsequently, the reaction was quenched by adding water (100 mL). Filtration of the resulting crystals afforded the title compound as a colorless powder (187 mg).

Workup

  1. additionsulfur trioxide-pyridine complex (829 mg) was added at once and the mixture
  2. stirringwas further stirred at room temperature for 1 hour
  3. customSubsequently, the reaction was quenched
  4. additionby adding water (100 mL)
  5. filtrationFiltration of the resulting crystals

Sources & evidence

ORD record
ord-15c21e2c88c84b3ba31a669aaffd280b
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

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