HCID 59389336, compound → HCID 59389321, compound

HRID 2357944Notes

Reaction equation

HRID 2357944 reaction equation
[OH:1][CH2:2][C:3]1[C:4]2[N:5]([N:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=2)[C:6]([CH2:9][O:10][CH3:11])=[CH:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:11][O:10][CH2:9][C:6]1[N:5]2[N:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=[C:4]2[C:3]([CH:2]=[O:1])=[CH:8][CH:7]=1

Participants

4

Reactant 1

HCID 59389336HCID 59389336, compound

Product 1

HCID 59389321HCID 59389321, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
50 °C

Procedure

Activated manganese dioxide (20.0 g) was added to a solution of the compound of Example 326 (6.00 g) in chloroform (120 mL). The reaction mixture was stirred at 50° C. for 5 hours. Subsequently, the mixture was filtered through Celite. The filtrate was concentrated to afford the title compound as a pale yellow powder (5.74 g).

Workup

  1. filtrationSubsequently, the mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-e8fb9fb736c44da28e5a8e133c142576
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

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