Water → HCID 59389384, compound

HRID 2357946Notes

Reaction equation

HRID 2357946 reaction equation
C(N(CC)CC)C.[OH:8][CH:9]([C:12]1[C:13]2[N:14]([N:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=2)[C:15]([CH2:18][O:19][CH3:20])=[CH:16][CH:17]=1)[CH2:10][CH3:11].O>CS(C)=O>[CH3:20][O:19][CH2:18][C:15]1[N:14]2[N:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=[C:13]2[C:12]([C:9](=[O:8])[CH2:10][CH3:11])=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 59389313HCID 59389313, compound

Product 1

HCID 59389384HCID 59389384, compoundYield 96.8%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Triethylamine (7.56 mL) was added to a solution of the compound of Example 328 (1.55 g) in dimethylsulfoxide (60 mL). While the solution was stirred at room temperature, sulfur trioxide-pyridine complex (4.28 g) was added and the mixture was stirred at room temperature for 1 hour. Subsequently, water (300 mL) was added. The resulting crystals were collected by filtration and thoroughly dried to afford the title compound as a colorless powder (1.49 g).

Workup

  1. additionsulfur trioxide-pyridine complex (4.28 g) was added
  2. stirringthe mixture was stirred at room temperature for 1 hour
  3. filtrationThe resulting crystals were collected by filtration
  4. customthoroughly dried

Sources & evidence

ORD record
ord-2c0d87e1e0ba4afeabf72c39594af462
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

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