HCID 59389290, compound → HCID 59389347, compound

HRID 2357955Notes

Reaction equation

HRID 2357955 reaction equation
[OH:1][CH2:2][C:3]1[C:4]2[N:5]([N:11]=[C:12]([C:14]([F:20])([F:19])[C:15]([F:18])([F:17])[F:16])[CH:13]=2)[C:6]([O:9][CH3:10])=[CH:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:10][O:9][C:6]1[N:5]2[N:11]=[C:12]([C:14]([F:20])([F:19])[C:15]([F:16])([F:17])[F:18])[CH:13]=[C:4]2[C:3]([CH:2]=[O:1])=[CH:8][CH:7]=1

Participants

4

Reactant 1

HCID 59389290HCID 59389290, compound

Product 1

HCID 59389347HCID 59389347, compoundYield 97.5%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
50 °C

Procedure

Activated manganese dioxide (3.75 g) was added to a solution of the compound of Example 353 (1.28 g) in chloroform (50 mL). The mixture was stirred at 50° C. for 4 hours. Subsequently, the mixture was filtered through Celite and the filtrate was concentrated to afford the title compound as a colorless powder (1.24 g).

Workup

  1. filtrationSubsequently, the mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-9921fcbb7d03473198d993a305a6919d
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

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