Ammonium Hydroxide → HCID 24890788, compound

HRID 2357975Notes

Reaction equation

HRID 2357975 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]3[CH:12]=[N:13][N:14]=[C:7]3[C@@H:6]([CH2:15][CH3:16])[N:5]([CH:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[C:4]=2[N:3]=1.[OH-].[NH4+:23]>>[CH:17]1([N:5]2[C:4]3[N:3]=[C:2]([NH2:23])[N:11]=[CH:10][C:9]=3[N:8]3[CH:12]=[N:13][N:14]=[C:7]3[C@H:6]2[CH2:15][CH3:16])[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 59389586(R)-7-chloro-5-cyclopentyl-4-ethyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

Product 1

HCID 24890788HCID 24890788, compoundYield 36%

Procedure

A solution of (R)-7-chloro-5-cyclopentyl-4-ethyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine (500 mg, 1.64 mmol) in ammonium hydroxide (10 ml) was heated under microwave irradiation at 140° C. for 30 minutes. The solvent was removed under reduced pressure and cold water (5 mL) was added. The resulting light brown solid was filtered under vacuum and washed with cold water to give the title compound (170 mg, 36% yield).

Workup

  1. customThe solvent was removed under reduced pressure and cold water (5 mL)
  2. additionwas added
  3. filtrationThe resulting light brown solid was filtered under vacuum
  4. washwashed with cold water

Sources & evidence

ORD record
ord-5740cb14dc4b45a9b0ee1e3691d66362
Source dataset
uspto-grants-2010_07
Patent number
US07763629B2

Reaction notes

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