HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → (S)-2-Hydroxy-N-methyl-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | methyl (2S)-2-hydroxy-2-phenylacetate | HCID 643570 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-2-Hydroxy-N-methyl-2-phenylacetamide | HCID 12281461 | — |
Reaction Steps
Methyl (S)-(+)-mandelate (17 g) is dissolved in a solution of methylamine in methanol (230 mL, 2.0 M) and kept at RT for 1 d. Another portion of methylamine in methanol (10 mL, 2.0 M) is added. A third portion of methylamine in methanol (10 mL, 2.0 M) is added one day later. After additional 24 h the solvents are removed in vacuo to give the desired mandelamide as pale yellow crystals, which are used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763638B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-ee307858920a47ca811f5f7b6b342cee |
| Source note | uspto-grants-2010_07 |