反应详情

Methyl (S)-(+)-mandelate (17 g) is dissolved in a solution of methylamine in methanol (230 mL, 2.0 M) and kept at RT for 1 d. Another portion of methylamine in methanol (10 mL, 2.0 M) is added. A third portion of methylamine in methanol (10 mL, 2.0 M) is added one day later. After additional 24 h the solvents are removed in vacuo to give the desired mandelamide as pale yellow crystals, which are used without further purification.

1. customAfter additional 24 h the solvents are removed in vacuo